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Tobacco Cessation

Smoking Cessation Interventions

This map provides structured access to an up to date, robust body of secondary evidence on interventions surrounding cessation of tobacco use, as per areas 2-4 of The Welsh Government Tobacco Control Action Plan for Wales. Sources included in the map may provide evidence which addresses the following question: what interventions are effective for smoking cessation?

Date of last search: June 2026. Next update due: June 2028

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Please note, you may need to scroll horizontally to see all the categories of evidence in the table.

	Population Groups
Interventions	Military/ ex military	Adults	Pre existing health condition	Pregnancy/ post-partum	Prisoner/ ex prisoner	Black, Asian and Minority Ethnic populations	General Population	Homeless	Children & Young adults	Current / previous history of substance misuse
Bupropion	Bupropion - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation	Bupropion - Adults Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Thomas KH el al (2021) Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Hajizadeh A et al (2023) Antidepressants for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Hollands GJ et al (2019) Interventions to increase adherence to medications for tobacco dependence Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation Cahill K et al (2013) Pharmacological interventions for smoking cessation: an overview and network meta-analysis National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [K] Evidence review for cessation and harm-reduction treatments National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Bupropion - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Hajizadeh A et al (2023) Antidepressants for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Zeng L et al (2019) Interventions for smoking cessation in people diagnosed with lung cancer Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Bupropion - Pregnancy/ post-partum Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Claire R et al (2020) Pharmacological interventions for promoting smoking cessation during pregnancy Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Bupropion - Prisoner/ ex prisoner	Bupropion - Black, Asian and Minority Ethnic populations Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Bupropion - General Population Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use CADTH (2016) Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Bell, K et al (2007) Smoking: workplace interventions Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Bupropion - Homeless Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Bupropion - Children & Young adults Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Lindson N et al (2019) Smoking reduction interventions for smoking cessation Fanshawe TR et al (2017) Tobacco cessation interventions for young people National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy	Bupropion - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Multicomponent Interventions	Multicomponent Interventions - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation	Multicomponent Interventions - Adults Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Jackson S et al (2022) Mindfulness for smoking cessation Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Hajizadeh A et al (2023) Antidepressants for smoking cessation Matkin W et al (2019) Telephone counselling for smoking cessation Carson-Chahhoud KV et al (2019) Community pharmacy personnel interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Hollands GJ et al (2019) Interventions to increase adherence to medications for tobacco dependence Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Stead LF et al (2016) Combined pharmacotherapy and behavioural interventions for smoking cessation Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation Cahill K et al (2013) Pharmacological interventions for smoking cessation: an overview and network meta-analysis David SP et al (2013) Opioid antagonists for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [K] Evidence review for cessation and harm-reduction treatments National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Notley C et al. (2025) Incentives for smoking cessation NICE (2025) Tobacco: preventing uptake, promoting quitting and treating dependence (update): evidence reviews for Cytisinicline Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Multicomponent Interventions - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Hajizadeh A et al (2023) Antidepressants for smoking cessation Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Zeng L et al (2019) Interventions for smoking cessation in people diagnosed with lung cancer Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Roelsgaard IK et al (2019) Smoking cessation intervention for reducing disease activity in chronic autoimmune inflammatory joint diseases Stead LF et al (2016) Combined pharmacotherapy and behavioural interventions for smoking cessation Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes Barth J et al (2015) Psychosocial interventions for smoking cessation in patients with coronary heart disease Thomsen T et al (2014) Interventions for preoperative smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Notley C et al. (2025) Incentives for smoking cessation	Multicomponent Interventions - Pregnancy/ post-partum Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Claire R et al (2020) Pharmacological interventions for promoting smoking cessation during pregnancy Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update. [H] Evidence reviews for opt-out stop smoking support National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [J] Evidence reviews for nicotine replacement therapies and e-cigarettes in pregnancy: update National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Notley C et al. (2025) Incentives for smoking cessation	Multicomponent Interventions - Prisoner/ ex prisoner	Multicomponent Interventions - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Multicomponent Interventions - General Population Jackson S et al (2022) Mindfulness for smoking cessation Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Taylor GMJ et al (2017) Internet-based interventions for smoking cessation Thomas D et al (2017) System change interventions for smoking cessation National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour National Institute for Health and Care Excellence (2018) Community pharmacy: Promoting health and wellbeing. Evidence reviews for offering advice or education to promote health and wellbeing National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [D] Evidence reviews for digital media as an adjunct National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Morgan et al (2012) Review 2: The effectiveness of tobacco harm reduction approaches with the intention of quitting (i.e. ‘cutting down to quit’ or ‘reduction to stop smoking’), with and without assistance Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Jepson, R et al (2006) A review of the effectiveness of mass media interventions which both encourage quit attempts and reinforce current and recent attempts to quit smoking	Multicomponent Interventions - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Multicomponent Interventions - Children & Young adults Jackson S et al (2022) Mindfulness for smoking cessation Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Matkin W et al (2019) Telephone counselling for smoking cessation Fanshawe TR et al (2017) Tobacco cessation interventions for young people National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy	Multicomponent Interventions - Current / previous history of substance misuse Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Apollonio D et al (2017) Interventions for tobacco use cessation in people in treatment for or recovery from substance use disorders Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Notley C et al. (2025) Incentives for smoking cessation
Other Psychosocial Therapies	Other Psychosocial Therapies - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation	Other Psychosocial Therapies - Adults Jackson S et al (2022) Mindfulness for smoking cessation Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation van den Brand FA et al (2017) Healthcare financing systems for increasing the use of tobacco dependence treatment Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Psychosocial Therapies - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Barth J et al (2015) Psychosocial interventions for smoking cessation in patients with coronary heart disease Thomsen T et al (2014) Interventions for preoperative smoking cessation Stead LF et al (2013) Physician advice for smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Psychosocial Therapies - Pregnancy/ post-partum Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence [I] Evidence reviews for incentives during pregnancy Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Psychosocial Therapies - Prisoner/ ex prisoner	Other Psychosocial Therapies - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Psychosocial Therapies - General Population Jackson S et al (2022) Mindfulness for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Fanshawe TR et al (2019) Competitions for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Other Psychosocial Therapies - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Psychosocial Therapies - Children & Young adults Jackson S et al (2022) Mindfulness for smoking cessation Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [E] Evidence reviews for Smokefree Class Competitions Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy	Other Psychosocial Therapies - Current / previous history of substance misuse Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Freijah I et al. (2026) Psychosocial interventions for supporting women to stop smoking in pregnancy Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Cognitive Behaviour Therapy	Cognitive Behaviour Therapy - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation	Cognitive Behaviour Therapy - Adults Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Stead LF et al (2017) Group behaviour therapy programmes for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV	Cognitive Behaviour Therapy - Pre existing health condition Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness	Cognitive Behaviour Therapy - Pregnancy/ post-partum Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness	Cognitive Behaviour Therapy - Prisoner/ ex prisoner	Cognitive Behaviour Therapy - Black, Asian and Minority Ethnic populations	Cognitive Behaviour Therapy - General Population Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Morgan et al (2012) Review 2: The effectiveness of tobacco harm reduction approaches with the intention of quitting (i.e. ‘cutting down to quit’ or ‘reduction to stop smoking’), with and without assistance	Cognitive Behaviour Therapy - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness	Cognitive Behaviour Therapy - Children & Young adults Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Lindson N et al (2019) Smoking reduction interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness	Cognitive Behaviour Therapy - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation
Alternative smoking cessation therapies	Alternative smoking cessation therapies - Military/ ex military	Alternative smoking cessation therapies - Adults	Alternative smoking cessation therapies - Pre existing health condition van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression	Alternative smoking cessation therapies - Pregnancy/ post-partum CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness	Alternative smoking cessation therapies - Prisoner/ ex prisoner	Alternative smoking cessation therapies - Black, Asian and Minority Ethnic populations	Alternative smoking cessation therapies - General Population Ussher MH et al (2019) Exercise interventions for smoking cessation Barnes J et al (2019) Hypnotherapy for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions White AR et al (2014) Acupuncture and related interventions for smoking cessation McRobbie, H et al (2007) Rapid Review of non-NHS treatments for smoking cessation	Alternative smoking cessation therapies - Homeless	Alternative smoking cessation therapies - Children & Young adults Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline	Alternative smoking cessation therapies - Current / previous history of substance misuse
Electronic Nicotine Delivery System	Electronic Nicotine Delivery System - Military/ ex military Lindson N et al (2024) Electronic cigarettes for smoking cessation	Electronic Nicotine Delivery System - Adults Thomas KH el al (2021) Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis Lindson N et al (2024) Electronic cigarettes for smoking cessation Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [K] Evidence review for cessation and harm-reduction treatments National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Lindson N et al. (2025) Electronic cigarettes for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Electronic Nicotine Delivery System - Pre existing health condition Lindson N et al (2024) Electronic cigarettes for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions Lindson N et al. (2025) Electronic cigarettes for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Electronic Nicotine Delivery System - Pregnancy/ post-partum Lindson N et al (2024) Electronic cigarettes for smoking cessation Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [J] Evidence reviews for nicotine replacement therapies and e-cigarettes in pregnancy: update National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Lindson N et al. (2025) Electronic cigarettes for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Electronic Nicotine Delivery System - Prisoner/ ex prisoner	Electronic Nicotine Delivery System - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Electronic Nicotine Delivery System - General Population Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Morgan et al (2012) Review 2: The effectiveness of tobacco harm reduction approaches with the intention of quitting (i.e. ‘cutting down to quit’ or ‘reduction to stop smoking’), with and without assistance	Electronic Nicotine Delivery System - Homeless Lindson N et al. (2025) Electronic cigarettes for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Electronic Nicotine Delivery System - Children & Young adults Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Lindson N et al. (2025) Electronic cigarettes for smoking cessation	Electronic Nicotine Delivery System - Current / previous history of substance misuse Lindson N et al. (2025) Electronic cigarettes for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Self-Help Materials	Self-Help Materials - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation	Self-Help Materials - Adults Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Livingstone-Banks J et al (2019) Print-based self-help interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Moyo et al (2018) Effectiveness of decision aids for smoking cessation in adults: a quantitative systematic review Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Self-Help Materials - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Barth J et al (2015) Psychosocial interventions for smoking cessation in patients with coronary heart disease van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Self-Help Materials - Pregnancy/ post-partum Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Self-Help Materials - Prisoner/ ex prisoner	Self-Help Materials - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Self-Help Materials - General Population Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation National Institute for Health and Care Excellence (2018) Community pharmacy: Promoting health and wellbeing. Evidence reviews for offering advice or education to promote health and wellbeing National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Bell, K et al (2007) Smoking: workplace interventions	Self-Help Materials - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Self-Help Materials - Children & Young adults Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Lindson N et al (2019) Smoking reduction interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy	Self-Help Materials - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Motivational Interviewing	Motivational Interviewing - Military/ ex military Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Lindson N et al (2019) Motivational interviewing for smoking cessation	Motivational Interviewing - Adults Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Carson-Chahhoud KV et al (2019) Community pharmacy personnel interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Lindson N et al (2019) Motivational interviewing for smoking cessation Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Motivational Interviewing - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Lindson N et al (2019) Motivational interviewing for smoking cessation Barth J et al (2015) Psychosocial interventions for smoking cessation in patients with coronary heart disease Stead LF et al (2013) Physician advice for smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia	Motivational Interviewing - Pregnancy/ post-partum Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care	Motivational Interviewing - Prisoner/ ex prisoner Lindson N et al (2019) Motivational interviewing for smoking cessation	Motivational Interviewing - Black, Asian and Minority Ethnic populations	Motivational Interviewing - General Population Lindson N et al (2019) Motivational interviewing for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions National Institute for Health and Care Excellence (2018) Community pharmacy: Promoting health and wellbeing. Evidence reviews for offering advice or education to promote health and wellbeing National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting	Motivational Interviewing - Homeless Lindson N et al (2019) Motivational interviewing for smoking cessation	Motivational Interviewing - Children & Young adults Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Lindson N et al (2019) Smoking reduction interventions for smoking cessation Lindson N et al (2019) Motivational interviewing for smoking cessation Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy	Motivational Interviewing - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Lindson N et al (2019) Motivational interviewing for smoking cessation
Behaviour Support	Behaviour Support - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Gierisch, JM et al (2017) The Effectiveness of Health Coaching	Behaviour Support - Adults Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Hajizadeh A et al (2023) Antidepressants for smoking cessation Matkin W et al (2019) Telephone counselling for smoking cessation Carson-Chahhoud KV et al (2019) Community pharmacy personnel interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Hollands GJ et al (2019) Interventions to increase adherence to medications for tobacco dependence Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Rice VH et al (2017) Nursing interventions for smoking cessation Stead LF et al (2017) Group behaviour therapy programmes for smoking cessation Lancaster T and Stead LF (2017) Individual behavioural counselling for smoking cessation Brown, T et al (2016) Community pharmacy interventions for public health priorities: a systematic review of community pharmacy-delivered smoking, alcohol and weight management interventions Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status NICE (2025) Tobacco: preventing uptake, promoting quitting and treating dependence (update): evidence reviews for Cytisinicline	Behaviour Support - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Hajizadeh A et al (2023) Antidepressants for smoking cessation Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Zeng L et al (2019) Interventions for smoking cessation in people diagnosed with lung cancer Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Roelsgaard IK et al (2019) Smoking cessation intervention for reducing disease activity in chronic autoimmune inflammatory joint diseases Gierisch, JM et al (2017) The Effectiveness of Health Coaching Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes Barth J et al (2015) Psychosocial interventions for smoking cessation in patients with coronary heart disease Thomsen T et al (2014) Interventions for preoperative smoking cessation Stead LF et al (2013) Physician advice for smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Behaviour Support - Pregnancy/ post-partum Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Claire R et al (2020) Pharmacological interventions for promoting smoking cessation during pregnancy Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update. [H] Evidence reviews for opt-out stop smoking support National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence [I] Evidence reviews for incentives during pregnancy National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Behaviour Support - Prisoner/ ex prisoner	Behaviour Support - Black, Asian and Minority Ethnic populations Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Behaviour Support - General Population Matkin W et al (2019) Telephone counselling for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Hartmann-Boyce J et al (2018) Nicotine replacement therapy versus control for smoking cessation Faseru B et al (2018) Enhancing partner support to improve smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use National Institute for Health and Care Excellence (2018) Community pharmacies: promoting health and wellbeing Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2018) Community pharmacy: Promoting health and wellbeing. Evidence reviews for offering advice or education to promote health and wellbeing National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Morgan et al (2012) Review 2: The effectiveness of tobacco harm reduction approaches with the intention of quitting (i.e. ‘cutting down to quit’ or ‘reduction to stop smoking’), with and without assistance Bell, K et al (2007) Smoking: workplace interventions Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Behaviour Support - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Behaviour Support - Children & Young adults Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Matkin W et al (2019) Telephone counselling for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Fanshawe TR et al (2017) Tobacco cessation interventions for young people Stead LF et al (2013) Physician advice for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness	Behaviour Support - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Apollonio D et al (2017) Interventions for tobacco use cessation in people in treatment for or recovery from substance use disorders Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Other Pharmacotherapies	Other Pharmacotherapies - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation	Other Pharmacotherapies - Adults Livingstone-Banks J et al (2023) Nicotine receptor partial agonists for smoking cessation (Review) Tattan-Birch H et al (2022) Heated tobacco products for smoking cessation and reducing smoking prevalence Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Hajizadeh A et al (2023) Antidepressants for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Cahill K et al (2013) Pharmacological interventions for smoking cessation: an overview and network meta-analysis David SP et al (2013) Opioid antagonists for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Pharmacotherapies - Pre existing health condition Hajizadeh A et al (2023) Antidepressants for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Pharmacotherapies - Pregnancy/ post-partum Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Pharmacotherapies - Prisoner/ ex prisoner	Other Pharmacotherapies - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Pharmacotherapies - General Population Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use Leaviss J et al (2014) What is the clinical effectiveness and cost effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation McRobbie, H et al (2007) Rapid Review of non-NHS treatments for smoking cessation	Other Pharmacotherapies - Homeless Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Other Pharmacotherapies - Children & Young adults Lindson N et al (2019) Smoking reduction interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence	Other Pharmacotherapies - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Nicotine Replacement Therapy	Nicotine Replacement Therapy - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation	Nicotine Replacement Therapy - Adults Theodoulou, A et al (2023) Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (Review) Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Thomas KH el al (2021) Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Hajizadeh A et al (2023) Antidepressants for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Hollands GJ et al (2019) Interventions to increase adherence to medications for tobacco dependence Brown, T et al (2016) Community pharmacy interventions for public health priorities: a systematic review of community pharmacy-delivered smoking, alcohol and weight management interventions Cahill K and Lancaster T (2014) Workplace interventions for smoking cessation Cahill K et al (2013) Pharmacological interventions for smoking cessation: an overview and network meta-analysis National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [K] Evidence review for cessation and harm-reduction treatments National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Wang, D et al (2008) 'Cut down to quit' with nicotine replacement therapies in smoking cessation: a systematic review of effectiveness and economic analysis Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status NICE (2025) Tobacco: preventing uptake, promoting quitting and treating dependence (update): evidence reviews for Cytisinicline Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Nicotine Replacement Therapy - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Hajizadeh A et al (2023) Antidepressants for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Zeng L et al (2019) Interventions for smoking cessation in people diagnosed with lung cancer Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes Thomsen T et al (2014) Interventions for preoperative smoking cessation van der Meer RM et al (2013) Smoking cessation interventions for smokers with current or past depression Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Nicotine Replacement Therapy - Pregnancy/ post-partum Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Claire R et al (2020) Pharmacological interventions for promoting smoking cessation during pregnancy Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation CADTH (2017) Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness Likis FE et al (2014) Smoking Cessation Interventions in Pregnancy and Postpartum Care National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [J] Evidence reviews for nicotine replacement therapies and e-cigarettes in pregnancy: update National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Nicotine Replacement Therapy - Prisoner/ ex prisoner	Nicotine Replacement Therapy - Black, Asian and Minority Ethnic populations Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Nicotine Replacement Therapy - General Population Theodoulou, A et al (2023) Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (Review) Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2018) Nicotine replacement therapy versus control for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use CADTH (2016) Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Morgan et al (2012) Review 2: The effectiveness of tobacco harm reduction approaches with the intention of quitting (i.e. ‘cutting down to quit’ or ‘reduction to stop smoking’), with and without assistance Bell, K et al (2007) Smoking: workplace interventions Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Nicotine Replacement Therapy - Homeless Vijayaraghavan M et al (2020) Interventions to reduce tobacco use in people experiencing homelessness Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Nicotine Replacement Therapy - Children & Young adults Holliday R et al (2021) Interventions for tobacco cessation delivered by dental professionals Selph, S et al (2020) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Lachance C and Frey N (2020) Non-Pharmacological and Pharmacological Interventions for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guideline Lindson N et al (2019) Smoking reduction interventions for smoking cessation Fanshawe TR et al (2017) Tobacco cessation interventions for young people National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2018) Smoking cessation interventions and services [B] Evidence reviews for interventions to aid smoking cessation: behavioural support and pharmacotherapy Myers, K et al (2012) Smoking cessation in Secondary Care Review 2 (Component 1) Smoking cessation interventions in acute and maternity services: Review of effectiveness	Nicotine Replacement Therapy - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Apollonio D et al (2017) Interventions for tobacco use cessation in people in treatment for or recovery from substance use disorders Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Universal Smoking Cessation Interventions	Universal Smoking Cessation Interventions - Military/ ex military Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation	Universal Smoking Cessation Interventions - Adults Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Petkovic J et al (2021) Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation CADTH (2019) Pharmacist-Led Interventions for Tobacco Smoking Cessation: A Review of Clinical Effectiveness and Cost-Effectiveness National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Universal Smoking Cessation Interventions - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Petkovic J et al (2021) Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Universal Smoking Cessation Interventions - Pregnancy/ post-partum National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England	Universal Smoking Cessation Interventions - Prisoner/ ex prisoner	Universal Smoking Cessation Interventions - Black, Asian and Minority Ethnic populations Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease	Universal Smoking Cessation Interventions - General Population Petkovic J et al (2021) Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population Whittaker R et al (2019) Mobile phone text messaging and app-based interventions for smoking cessation Tzelepis F et al (2019) Real-time video counselling for smoking cessation Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation Taylor GMJ et al (2017) Internet-based interventions for smoking cessation Thomas D et al (2017) System change interventions for smoking cessation Hollands GJ et al (2015) Portion, package or tableware size for changing selection and consumption of food, alcohol and tobacco National Institute for Health and Care Excellence (2018) Community pharmacies: promoting health and wellbeing Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour National Institute for Health and Care Excellence (2018) Community pharmacy: Promoting health and wellbeing. Evidence reviews for offering advice or education to promote health and wellbeing National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting Bell, K et al (2007) The Impact of Quitlines on Smoking Cessation Bell, K et al (2007) The Effectiveness of National Health Service Intensive Treatments for Smoking Cessation in England Jepson, R et al (2006) A review of the effectiveness of mass media interventions which both encourage quit attempts and reinforce current and recent attempts to quit smoking	Universal Smoking Cessation Interventions - Homeless	Universal Smoking Cessation Interventions - Children & Young adults National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2020) Behaviour change: digital and mobile health interventions Evidence review A: smoking behaviour	Universal Smoking Cessation Interventions - Current / previous history of substance misuse Clair C et al (2019) Biomedical risk assessment as an aid for smoking cessation
Varenicline	Varenicline - Military/ ex military Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation	Varenicline - Adults Livingstone-Banks J et al (2023) Nicotine receptor partial agonists for smoking cessation (Review) Asfar T et al (2023) Interventions for waterpipe smoking cessation (Review) Thomas KH el al (2021) Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Hajizadeh A et al (2023) Antidepressants for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Hollands GJ et al (2019) Interventions to increase adherence to medications for tobacco dependence Cahill K et al (2013) Pharmacological interventions for smoking cessation: an overview and network meta-analysis National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [K] Evidence review for cessation and harm-reduction treatments National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Mdege ND et al. (2024) Interventions for tobacco use cessation in people living with HIV Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status Sharrad KJ et al. (2026) Training health professionals in smoking cessation	Varenicline - Pre existing health condition Lindson N et al (2021) Strategies to improve smoking cessation rates in primary care Hajizadeh A et al (2023) Antidepressants for smoking cessation Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Zeng L et al (2019) Interventions for smoking cessation in people diagnosed with lung cancer Jeyashree K et al (2016) Smoking cessation interventions for pulmonary tuberculosis treatment outcomes Thomsen T et al (2014) Interventions for preoperative smoking cessation Tsoi DT et al (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [O] Evidence review for tailored interventions for those with mental health conditions Leonardi-Bee, J et al (2012) Review 4: Effectiveness of Smoking cessation interventions in Mental health Streck JM et al. (2024) Interventions for smoking cessation in hospitalised patients Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Varenicline - Pregnancy/ post-partum Patnode CD et al (2021) Interventions for Tobacco Cessation in Adults, Including Pregnant Women: An Evidence Update for the U.S. Preventive Services Task Force Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Varenicline - Prisoner/ ex prisoner	Varenicline - Black, Asian and Minority Ethnic populations Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Varenicline - General Population Livingstone-Banks J et al (2019) Relapse prevention interventions for smoking cessation Health Information and Quality Authority Ireland (2017) Health Technology Assessment (HTA) of Smoking Cessation Interventions Lindson-Hawley N et al (2016) Interventions to reduce harm from continued tobacco use CADTH (2016) Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness Leaviss J et al (2014) What is the clinical effectiveness and cost effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation Scottish Intercollegiate Guidelines Network (2017) Risk estimation and the prevention of cardiovascular disease National Institute for Health and Care Excellence (2013) Tobacco: harm-reduction approaches to smoking. Review 3: The effectiveness of long-term harm reduction approaches without the prior intention of quitting	Varenicline - Homeless Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Varenicline - Children & Young adults Lindson N et al (2019) Smoking reduction interventions for smoking cessation National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence National Institute for Health and Care Excellence (2021) Tobacco: preventing uptake, promoting quitting and treating dependence: update [N] Evidence reviews for smoking relapse prevention	Varenicline - Current / previous history of substance misuse Lindson N et al (2019) Smoking reduction interventions for smoking cessation Hartmann-Boyce J et al (2019) Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status
Nicotine pouches	Nicotine pouches - Military/ ex military	Nicotine pouches - Adults Hartmann-Boyce J et al (2025) Oral nicotine pouches for cessation or reduction of use of other tobacco or nicotine products	Nicotine pouches - Pre existing health condition	Nicotine pouches - Pregnancy/ post-partum	Nicotine pouches - Prisoner/ ex prisoner	Nicotine pouches - Black, Asian and Minority Ethnic populations	Nicotine pouches - General Population	Nicotine pouches - Homeless	Nicotine pouches - Children & Young adults	Nicotine pouches - Current / previous history of substance misuse
Cytisinicline (Cytisine)	Cytisinicline (Cytisine) - Military/ ex military	Cytisinicline (Cytisine) - Adults Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status NICE (2025) Tobacco: preventing uptake, promoting quitting and treating dependence (update): evidence reviews for Cytisinicline	Cytisinicline (Cytisine) - Pre existing health condition Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Cytisinicline (Cytisine) - Pregnancy/ post-partum Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Cytisinicline (Cytisine) - Prisoner/ ex prisoner	Cytisinicline (Cytisine) - Black, Asian and Minority Ethnic populations Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Cytisinicline (Cytisine) - General Population	Cytisinicline (Cytisine) - Homeless Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status	Cytisinicline (Cytisine) - Children & Young adults	Cytisinicline (Cytisine) - Current / previous history of substance misuse Theodoulou A et al. (2025) Differences in the effectiveness of individual‐level smoking cessation interventions by socioeconomic status

Tobacco Cessation

Smoking Cessation Interventions

Population Groups

Interventions

Bupropion - Military/ ex military

Bupropion - Adults

Bupropion - Pre existing health condition

Bupropion - Pregnancy/ post-partum

Bupropion - Prisoner/ ex prisoner

Bupropion - Black, Asian and Minority Ethnic populations

Bupropion - General Population

Bupropion - Homeless

Bupropion - Children & Young adults

Bupropion - Current / previous history of substance misuse

Multicomponent Interventions - Military/ ex military

Multicomponent Interventions - Adults

Multicomponent Interventions - Pre existing health condition

Multicomponent Interventions - Pregnancy/ post-partum

Multicomponent Interventions - Prisoner/ ex prisoner

Multicomponent Interventions - Black, Asian and Minority Ethnic populations

Multicomponent Interventions - General Population

Multicomponent Interventions - Homeless

Multicomponent Interventions - Children & Young adults

Multicomponent Interventions - Current / previous history of substance misuse

Other Psychosocial Therapies - Military/ ex military

Other Psychosocial Therapies - Adults

Other Psychosocial Therapies - Pre existing health condition

Other Psychosocial Therapies - Pregnancy/ post-partum

Other Psychosocial Therapies - Prisoner/ ex prisoner

Other Psychosocial Therapies - Black, Asian and Minority Ethnic populations

Other Psychosocial Therapies - General Population

Other Psychosocial Therapies - Homeless

Other Psychosocial Therapies - Children & Young adults

Other Psychosocial Therapies - Current / previous history of substance misuse

Cognitive Behaviour Therapy - Military/ ex military

Cognitive Behaviour Therapy - Adults

Cognitive Behaviour Therapy - Pre existing health condition

Cognitive Behaviour Therapy - Pregnancy/ post-partum

Cognitive Behaviour Therapy - Prisoner/ ex prisoner

Cognitive Behaviour Therapy - Black, Asian and Minority Ethnic populations

Cognitive Behaviour Therapy - General Population

Cognitive Behaviour Therapy - Homeless

Cognitive Behaviour Therapy - Children & Young adults

Cognitive Behaviour Therapy - Current / previous history of substance misuse

Alternative smoking cessation therapies - Military/ ex military

Alternative smoking cessation therapies - Adults

Alternative smoking cessation therapies - Pre existing health condition

Alternative smoking cessation therapies - Pregnancy/ post-partum

Alternative smoking cessation therapies - Prisoner/ ex prisoner

Alternative smoking cessation therapies - Black, Asian and Minority Ethnic populations

Alternative smoking cessation therapies - General Population

Alternative smoking cessation therapies - Homeless

Alternative smoking cessation therapies - Children & Young adults

Alternative smoking cessation therapies - Current / previous history of substance misuse

Electronic Nicotine Delivery System - Military/ ex military

Electronic Nicotine Delivery System - Adults

Electronic Nicotine Delivery System - Pre existing health condition

Electronic Nicotine Delivery System - Pregnancy/ post-partum

Electronic Nicotine Delivery System - Prisoner/ ex prisoner

Electronic Nicotine Delivery System - Black, Asian and Minority Ethnic populations

Electronic Nicotine Delivery System - General Population

Electronic Nicotine Delivery System - Homeless

Electronic Nicotine Delivery System - Children & Young adults

Electronic Nicotine Delivery System - Current / previous history of substance misuse

Self-Help Materials - Military/ ex military

Self-Help Materials - Adults

Self-Help Materials - Pre existing health condition

Self-Help Materials - Pregnancy/ post-partum

Self-Help Materials - Prisoner/ ex prisoner

Self-Help Materials - Black, Asian and Minority Ethnic populations

Self-Help Materials - General Population

Self-Help Materials - Homeless

Self-Help Materials - Children & Young adults

Self-Help Materials - Current / previous history of substance misuse

Motivational Interviewing - Military/ ex military

Motivational Interviewing - Adults

Motivational Interviewing - Pre existing health condition

Motivational Interviewing - Pregnancy/ post-partum

Motivational Interviewing - Prisoner/ ex prisoner

Motivational Interviewing - Black, Asian and Minority Ethnic populations